Ligand and substrate effects during Pd-catalyzed cyclizations of alkyne-tethered cyclohexadienones.
نویسندگان
چکیده
The effects of ligand and substrate choice on the Pd-catalyzed cyclization of alkyne-tethered cyclohexadienones were examined. In the presence of a chiral ligand, the enantioselectivity of the desymmetrization is remarkably sensitive to structural changes in both the ligand and the substrate. Additionally, the regioselectivity of the reaction (5- vs. 6-membered ring formation) is dependent on the proximity of heteroatoms to the alkyne.
منابع مشابه
Regioselective and stereoselective cyclizations of cyclohexadienones tethered to active methylene groups.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 34 شماره
صفحات -
تاریخ انتشار 2013